The ADAM17 (a disintegrin and metalloprotease (ADAM) domain 17) is a member of the ADAM proteinfamily. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The ADAM17 functionsas a tumor necrosis factor-alpha converting enzyme.It binds mitotic arrest deficient 2 protein and also plays a prominent role in the activation of the Notch signaling pathway
Host
Rabbit
Immunogen
Rabbit polyclonal ADAM17 antibody was raised against a peptide from near the C terminal residues of human ADAM17 protein.
Isotype
IgG
Quantity
100 µl
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Shipping Condition
Ice Packs
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Concentration
100µg/100ul
Format
Liquid
Purity
Affinity purified
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
ELISA
Description
For research use onlyPeptide ELISA titer: 1:1,000-1:10,000Western blot analysis: 1:200-1,000Immunohistochemistry: 1:100-500Optimal dilutions/concentrations should be determined by the end use., ELISA
Dilution
ELISA
1:1,000-1:10,000
WB
1:200-1,000
IHC
1:100-500
Reference
Karbiener, M et al. "MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes." Stem Cells : (2013). DOI: 10.1002/stem.1603. PubMed: 24375761 . Application: Western Blot.