Anti-ACER1 Antibody

Mfr.No.	Y058546
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
Host	Rabbit
Quantity	100 µl
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: Human
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC, ELISA

Description

Peptide ELISA titer: 1:5,000-1:10,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-500
Optimal dilutions/concentrations should be determined by the end use., WB ; IHC ; ELISA

Dilution

ELISA	1:5,000-1:10,000
WB	1:500-1:1,000
IHC	1:100-500

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SKU	Supplier No.	Size	Your price	Quantity
BHA10915529	Y058546	100 ul	$217.50		Add to Cart

Anti-ACER1 Antibody

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