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Home / Primary Antibodies

Anti-Abeta (1-40/42) | 4D8 | oligomer specific monoclonal targeting amyloid-beta Antibody

SKU : BHA10922152

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y030015
Categories	Primary Antibodies
Clonality	monoclonal
Description	Alzheimer's disease is a progressive neurodegenerative disorder characterized by neurofibrillary tangles and depositionof plaques containing the amyloid-ÃŸ (AÃŸ) peptide. AÃŸ is derived through proteolytic cleavage of the amyloid precursor protein resulting in various peptide lengths corresponding to 38-43 amino acids. AÃŸ1-42 is particularly prone to self-aggregate and its aggregates are strongly linked to development of the disease. During in vitro AÃŸ self-assembly, highly cytotoxic metastable intermediates (oligomers) are generated ranging from 8 kDa to over 100 kDa. Several reports suggest a similar situation in vivo. We have generated a monoclonal antibody, specific for AÃŸ oligomers, by immunizing mice with partly aggregated AÃŸ1-40 peptide. The antibody 4D8 is a conformational specific antibody that specifically can detect oligomeric structures of AÃŸ (1-42). The reactivity is strongly enhanced within an oligomeric range of approximately 4-15 AÃŸ monomers while it shows only very low affinity towards mature fibrils and soluble monomers.
Formulation	Liquid
Host	Mouse(Mu)
Guarantee	abm guarantees that all our Anti-Abeta (1-40/42) ; 4D8 ; oligomer specific monoclonal targeting amyloid-beta Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	Partly aggregated, recombinant peptide corresponding to the human Abeta (1-40). Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V
Isotype	IgM
Quantity	25 μg
Recommended Dilution	Coating antibody at 2 µg/ml (ELISA), 1: 500 (IHC)
Shipping Condition	Ice Packs
Species Reactivity	Human
Specificity	No confirmed exceptions from predicted reactivity known in the moment

Gene Name	Aβ (1-40-42)
Clone No	Monoclonal

Concentration	0.5µg/1ul
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.02% sodium azide.
Storage Condition	-20C

Description	ELISA ; IHC

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SKU	Supplier No.	Size	Your price	Quantity
BHA10922152	Y030015	25 ug	$1275		Add to Cart

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