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Home / Primary Antibodies / Monoclonal Antibodies

Alpha Synuclein Antibody, Clone 4F1 (SMC-533)

BHA11905787
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+1 866.986.9598
Email
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Antigen Alpha Synuclein
Swissprot O55042
Accession Number NP_001035916.1
Gene Id 20617
Target Alpha Synuclein
Clone No 4F1
Research Area Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Buffer PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration 1 mg/ml
Dilutions WB (1:1000); DB (1:1000); IHC (1:200); ICC/IF (1:100); ELISA (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Purity Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Scientific Background Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4).
SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Shipping Temperature Blue Ice or 4°C
Specificity Binds multiple linear epitopes within human alpha synuclein: 21-70 aa, 61-90 aa, and 101-140 aa, determined using Dot blot and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~40 kDa is a trimer.
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications ELISA, IHC, DB, WB, ICC/IF
Description WB ; DB ; IHC ; ICC ; IF ; ELISA
Dilution WB (1:1000); DB (1:1000); IHC (1:200); ICC/IF (1:100); ELISA (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).

2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.

3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.

4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.

5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.

6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11905787-1 SMC-533D Unconjugated 100 ug $337
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BHA11905787-2 SMC-533D-A390 ATTO 390 100 ug $392
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BHA11905787-3 SMC-533D-A488 ATTO 488 100 ug $391
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BHA11905787-4 SMC-533D-A594 ATTO 594 100 ug $391
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BHA11905787-5 SMC-533D-APC APC 100 ug $390
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BHA11905787-6 SMC-533D-BI Biotin 100 ug $386
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BHA11905787-7 SMC-533D-FITC FITC 100 ug $381
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BHA11905787-8 SMC-533D-HRP HRP 100 ug $377
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BHA11905787-9 SMC-533D-PCP PerCP 100 ug $390
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BHA11905787-10 SMC-533D-RPE RPE 100 ug $388
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BHA11905787-11 SMC-533S Unconjugated 12 ug $45
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