AFP encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. Alpha fetoprotein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly
Clonality
Monoclonal
Formulation
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Host
Mouse
Immunogen
Synthetic Peptide
Isotype
Mouse IgG1
Reactivity
Human
Gene Id
174
Concentration
1 mg/ml
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Storage Buffer
PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol
Applications
Protein General Reagents
Reviews of AFP alpha-1 Fetoprotein Monoclonal Antibody