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Home / Primary Antibodies / Polyclonal Antibodies

XRCC1 Antibody

SKU : BHA17104310

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NSJ Bioreagents

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Mfr.No.	R30722
Clonality	Polyclonal
Description	X-ray repair, complementing defective, in chinese hamster 1 is a DNA repair protein which complexes with DNA ligase III. The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. The XRCC1 gene is mapped to 19q13.31. The protein interacts with DNA ligase III, polymerase beta and poly(ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of ser518, thr519, and thr523 largely determines aprataxin binding to XRCC1 through its FHA domain.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the N-terminus of human XRCC1 (QDSTHCAENLLKADTYRKWR) was used as the immunogen for this XRCC1 antibody (100% mouse homology).
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Rat, Human, Mouse
Recombinant	No

Antigen	XRCC1
Uniprot	P18887

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the XRCC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	IHC-P, WB, ICC
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17104310-1	R30722	100ug	$439		Add to Cart

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