Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers(CPD), sites of DNA damage after UV irradiation.
Categories
Primary Antibodies
Cellular Localization
Nucleus
Clonality
polyclonal
Description
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Host
Rabbit
Immunogen
xeroderma pigmentosum, complementation group A
Isotype
IgG
Molecular Weight
42 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Nucleus
Synonyms
XP1, XPA, XPAC
Antigen
XPA
Uniprot
P23025
Gene Id
7507
Research Area
Epigenetics, Metabolism
Weight
42kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)