Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
Categories
Primary Antibodies
Cellular Localization
Extracellular matrix, Secreted
Clonality
polyclonal
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
Host
Rabbit
Immunogen
wingless-type MMTV integration site family, member 6
Isotype
IgG
Molecular Weight
40 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Subcellular Location
Extracellular matrix, Secreted
Synonyms
Protein Wnt 6, WNT6
Antigen
WNT6
Uniprot
Q9Y6F9
Gene Id
7475
Research Area
Developmental biology, Cardiovascular, Signal Transduction, Neuroscience
Weight
40kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)