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Home / Primary Antibodies / Polyclonal Antibodies

VWF, VWFpp antibody

SKU : BHA10809440

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Mfr.No.	FNab09466
Alternative Names	F8VWF ; vonWillebrandantigenII ; vonWillebrandfactor ; VWD ; VWF
Background	Von Willebrand factor(vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII(FVIII). Deficiency of vWF results in von Willebrand disease(vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2,813 amino acids(aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide(vWF propeptide, vWFpp, also called von Willebrand antigen II) and 2,050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region of pre-pro-vWF recognizes von Willebrand antigen 2(75-83 kDa) and pro-vWF(309-320 kDa).
Categories	Primary Antibodies
Cellular Localization	Extracellular matrix, Secreted
Clonality	polyclonal
Description	Von Willebrand factor (vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII (FVIII). Deficiency of vWF results in von Willebrand disease (vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2,813 amino acids (aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide (vWF propeptide, vWFpp, also called von Willebrand antigen II) and 2,050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region (residues 56-256 aa) of pre-pro-vWF recognizes von Willebrand antigen 2 (75-83 kDa) and pro-vWF (309-320 kDa). (PMID: 9759493; 12067899; 22452980; 8874191)
Host	Rabbit
Immunogen	von Willebrand factor
Isotype	IgG
Molecular Weight	75 kDa,309 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Extracellular matrix, Secreted
Synonyms	F8VWF, von Willebrand antigen II, von Willebrand factor, VWD, VWF

Uniprot	P04275
Research Area	Immunology, Cardiovascular
Weight	309kDa,observed 70kDa，309kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:100-1:400

Tested Application

WB: 1:200-1:2000; IHC: 1:100-1:400

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809440	FNab09466	100ug	$260		Add to Cart

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