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Home / Primary Antibodies / Polyclonal Antibodies

UIMC1 antibody

SKU : BHA10809236

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Mfr.No.	FNab09247
Alternative Names	BRCA1AcomplexsubunitRAP80 ; RAP80 ; Receptorassociatedprotein80 ; RXRIP110 ; UIMC1 ; X2HRIP110
Background	Ubiquitin-binding protein(PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin(PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks(DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Host	Rabbit
Immunogen	ubiquitin interaction motif containing 1
Isotype	IgG
Molecular Weight	97 kDa,80 kDa,71-75 kDa,61 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	BRCA1 A complex subunit RAP80, RAP80, Receptor associated protein 80, RXRIP110, UIMC1, X2HRIP110

Antigen	UIMC1
Uniprot	Q96RL1
Gene Id	51720
Research Area	Metabolism
Weight	80kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF, IHC

Description

ELISA ; WB ; IF ; IHC ; IF

Dilution

WB	1:200-1:1000
IP	1:200-1:2000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:200-1:1000; IP: 1?200-1?2000?IHC: 1?20-1?200; IF: 1?10-1?100

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809236	FNab09247	100ug	$280		Add to Cart

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