E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Host
Rabbit
Immunogen
ubiquitin protein ligase E3C
Isotype
IgG
Molecular Weight
120 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
KIAA0010, KIAA10, UBE3C, ubiquitin protein ligase E3C
Antigen
UBE3C
Uniprot
Q15386
Gene Id
9690
Research Area
Epigenetics, Metabolism
Weight
74kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)