Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies(MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Endosome
Clonality
polyclonal
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
Host
Rabbit
Immunogen
ubiquitin associated protein 1
Isotype
IgG
Molecular Weight
55 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm, Endosome
Synonyms
NAG20, UAP, UBAP, UBAP 1, UBAP1, ubiquitin associated protein 1
Antigen
UBAP1
Uniprot
Q9NZ09
Gene Id
51271
Research Area
Metabolism
Weight
55kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)