DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin(Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex(RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Nucleus
Clonality
polyclonal
Description
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Host
Rabbit
Immunogen
translin
Isotype
IgG
Molecular Weight
26 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Subcellular Location
Cytoplasm, Nucleus
Synonyms
REHF 1, translin, TRSLN, TSN
Antigen
TSN
Uniprot
Q15631
Gene Id
7247
Research Area
Metabolism
Weight
26kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)