TSHR (Thyroid-Stimulating Hormone Receptor), also called LGR3, is mapped to 14q31.1. The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 515-538 (ITLERWYAITFAMRLDRKIRLRHA) from the beta subunit of the human protein were used as the immunogen for the TSH Receptor antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Rat, Mouse
Recombinant
No
Antigen
Thyroid Stimulating Hormone Receptor / TSHR
Uniprot
P16473
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the TSH Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.