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Home / Primary Antibodies / Polyclonal Antibodies

TSG101 antibody

SKU : BHA10809032

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Mfr.No.	FNab09040
Alternative Names	ESCRTIcomplexsubunitTSG101 ; TSG10 ; TSG101 ; tumorsusceptibilitygene101 ; VPS23
Background	The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Host	Rabbit
Immunogen	tumor susceptibility gene 101
Isotype	IgG
Molecular Weight	44 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ESCRT I complex subunit TSG101, TSG10, TSG101, tumor susceptibility gene 101, VPS23

Antigen	TSG101
Uniprot	Q99816
Gene Id	7251
Research Area	Cell Division and Proliferation, Developmental biology, Cardiovascular, Metabolism
Weight	46kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, IP, FC

Description

ELISA ; WB ; IHC ; IF ; IP ; FC

Dilution

WB	1:200-1:2000
IP	1:200-1:2000
IHC	1:100-1:400
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab09040.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809032	FNab09040	100ug	$260		Add to Cart

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