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Home / Primary Antibodies / Polyclonal Antibodies

TRIF Antibody

SKU : BHA17104521

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NSJ Bioreagents

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Mfr.No.	R31002
Clonality	Polyclonal
Description	TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with <a href=../search_result.php?search_txt=TLR3>TLR3</a>, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either <a href=../search_result.php?search_txt=nfkb>NFKB</a>, <a href=../search_result.php?search_txt=ap1>AP1</a>, or <a href=../search_result.php?search_txt=irf3>IRF3</a>. TRIF activation of NFKB was found to occur predominantly through <a href=../search_result.php?search_txt=irak1>IRAK1</a> rather than <a href=../search_result.php?search_txt=irak2>IRAK2</a>. siRNA blockage of the protein reduced IFNB production in response to dsRNA.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human TRIF (NNHMWNQRGSQAPEDKTQEAE) was used as the immunogen for this TRIF antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	TRIF
Uniprot	Q8IUC6

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the TRIF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	IHC-F, IHC-P, WB
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,Immunohistochemistry (Frozen): 0.5-1ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17104521-1	R31002	100ug	$439		Add to Cart

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