TRIB1 Antibody (CSB-PA836296LA01HU)

Mfr.No.	CSB-PA836296LA01HU
Alternative Names	Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1), TRIB1, C8FW GIG2 TRB1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Host	Rabbit
Immunogen	Recombinant Human Tribbles homolog 1 protein (3-91AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Species	Homo Sapiens (Human)

Antigen	TRIB1
Uniprot	Q96RU8
Database Links	HGNC:16891 OMIM:609461 KEGG:hsa:10221 STRING:9606.ENSP00000312150 UniGene:Hs.444947
Function	Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily
Research Area	Signal Transduction
Tissue Specificity	Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:5000
IF	1:50-1:200

Tested Application

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10532726	CSB-PA836296LA01HU	50ug	$166		Add to Cart
BHA10532726	CSB-PA836296LA01HU	100ug	$299		Add to Cart

TRIB1 Antibody (CSB-PA836296LA01HU)

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