Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. It has also been designated as CD288 (cluster of differentiation 288). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognises G-rich oligonucleotides.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of the rat protein (ENDSRYDNLYIDSIRQY) was used as the immunogen for this TLR8 antibody.
Isotype
Ig
Predicted Reactivity
Rat, Mouse
Reactivity
Mouse, Rat
Recombinant
No
Antigen
TLR8
Uniprot
A5H300
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the TLR8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.