Toll-like receptor 1(TLR1), also called TIL or CD281 is a member of the Toll-like receptor family(TLR) of pattern recognition receptors of the innate immune system. This gene is mapped to 4p14 by fluorescence in situ hybridization. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human TLR1 (NLRAAINIKLTEQAKK) was used as the immunogen for this TLR1 antibody.
Isotype
Ig
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
TLR1
Uniprot
Q15399
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the TLR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.