TIA-1 (T-Cell Intracellular Antigen-1), also called WDM, is an RNA-binding protein involved in splicing regulation and translational repression. It is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte(CTL) target cells. By in situ hybridization, the gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is though to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the N-terminus of human TIA1 (STQRSQDHFHVFV) was used as the immunogen for this TIA-1 antibody (100% mouse homology).
Isotype
IgG
Predicted Reactivity
Human, Mouse
Reactivity
Mouse, Human
Recombinant
No
Antigen
TIA-1
Uniprot
P31483
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the TIA-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.