Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
Host
Rabbit
Immunogen Region
Recombinant human protein (amino acids Q119-R341) was used as the immunogen for the Telomeric repeat-binding factor 1 antibody.
Isotype
Rabbit IgG
Reactivity
Human
Recombinant
No
Antigen
TRF1
Uniprot
P54274
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Concentration
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format
Antigen affinity purified
Purification
Antigen affinity purified
Storage
After reconstitution, the Telomeric repeat-binding factor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Applications
Direct ELISA, IF, WB
Dilution
Western blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml,Direct ELISA: 0.1-0.5ug/ml