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Home / Primary Antibodies / Polyclonal Antibodies

TCHP Antibody, FITC conjugated (CSB-PA874804LC01HU)

SKU : BHA10516633

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA874804LC01HU
Alternative Names	Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein), TCHP
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).
Host	Rabbit
Immunogen	Recombinant Human Trichoplein keratin filament-binding protein (1-498AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm, cytoskeleton, Cytoplasm, Cell membrane, Mitochondrion, Cell junction, desmosome

Antigen	TCHP
Uniprot	Q9BT92
Database Links	HGNC:28135 OMIM:612654 KEGG:hsa:84260 STRING:9606.ENSP00000324404 UniGene:Hs.410924
Function	Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells
Protein Families	TCHP family
Research Area	Others
Tissue Specificity	Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest le

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Applications	ELISA
Description	ELISA
Tested Application	ELISA

Datasheet
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10516633	CSB-PA874804LC01HU	50ug	$166		Add to Cart
BHA10516633	CSB-PA874804LC01HU	100ug	$299		Add to Cart

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