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Home / Primary Antibodies / Polyclonal Antibodies

SIP1 Antibody / ZEB2

SKU : BHA17104565

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NSJ Bioreagents

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Mfr.No.	R31062
Clonality	Polyclonal
Description	Zinc finger E-box-binding homeobox 2, also known as Smad Interacting Protein 1 (SIP1) or Zinc finger homeobox 1B (ZFHX1B), is a protein that in humans is encoded by the ZEB2 gene. The gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated<a href=../search_result.php?search_txt=smad>SMADs</a>, the transducers of<a href=../search_result.php?search_txt=tgf beta>TGF-beta</a>signaling, and interacts with the nucleosome remodeling and histone deacetylation(NURD) complex. By radiation hybrid analysis, Nagase et al.(1998) mapped the gene to chromosome 2. Wakamatsu et al.(2001) mapped the gene to chromosome 2q22. Vandewalle et al.(2005) showed that expression of mouse Sip1 in human epithelial cells caused a morphologic change from an epithelial to a mesenchymal phenotype. Expression of<a href=../search_result.php?search_txt=snai1>SNAI1</a>in epithelial cells triggers an epithelial-mesenchyme transition. Beltran et al.(2008) showed that synthesis of SIP1 was upregulated following SNAI1 expression in human cell lines.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human Smad Interacting Protein 1 (DMQQRRKYQRKQGFQ) was used as the immunogen for this SIP1 antibody (100% homologous in human, mouse and rat).
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Antigen	SIP1
Uniprot	O60315

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the SIP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Western blot: 0.5-1ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17104565-1	R31062	100ug	$439		Add to Cart

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