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Home / Primary Antibodies / Polyclonal Antibodies

SHP2 Antibody / PTPN11

SKU : BHA17104013

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NSJ Bioreagents

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Mfr.No.	R30279
Clonality	Polyclonal
Description	The tyrosine phosphatase SHP2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. It can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation. SHP2 is specifically required in mesenchyme cells of the progress zone(PZ), directly beneath the distal ectoderm of the limb bud. Rather than integrating proliferative signals, it probably exerts its effects on limb development by influencing cell shape, movement or adhesion. Furthermore, the branchial arches, which also use Fgfs during bud outgrowth, similarly require Shp2. Thus, it regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human SHP2 (EDSARVYENVGLMQQ) was used as the immunogen for this SHP2 antibody (100% homologous in human, mouse and rat).
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	SHP2
Uniprot	Q06124

Buffer	Lyophilized from 1X PBS with 2% Trehalose
Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the SHP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104013	R30279	100ug	$439		Add to Cart

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