Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho-or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac(By similarity).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).
Host
Rabbit
Immunogen
SH3-domain binding protein 1
Isotype
IgG
Molecular Weight
76-80 kDa,51 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Antigen
SH3BP1
Uniprot
Q9Y3L3
Gene Id
23616
Research Area
Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)