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Home / Primary Antibodies / Polyclonal Antibodies

Securin Antibody

SKU : BHA17104791

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Mfr.No.	R31364
Clonality	Polyclonal
Description	Securin, also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex(APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. Securin contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box(D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	Amino acids 146-161 (LMILDEERELEKLFQL-human) were used as the immunogen for this Securin antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	Securin
Uniprot	O95997

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the Securin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Western blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104791	R31364	100ug	$439		Add to Cart

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