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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Rat Aquaporin 4 Polyclonal (SPC-505)

SKU : BHA11907938

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StressMarq Biosciences Inc.

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Mfr.No.	SPC-505, SPC-505D, SPC-505D-A390, SPC-505D-A488, SPC-505D-A594, SPC-505D-APC, SPC-505D-BI, SPC-505D-FITC, SPC-505D-HRP, SPC-505D-PCP, SPC-505D-RPE, SPC-505S
Immunogen Species	Rat
Alternative Names	AQP 4 Antibody, AQP-4 Antibody, AQP4 Antibody, AQP4_HUMAN Antibody, Aquaporin type 4 Antibody, Aquaporin-4 Antibody, Aquaporin4 Antibody, HMIWC 2 Antibody, HMIWC2 Antibody, Mercurial insensitive water channel Antibody, Mercurial-insensitive water channel Antibody, MGC22454 Antibody, MIWC Antibody, WCH 4 Antibody, WCH4 Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	0.5 ug/ml of SPC-505 was sufficient for detection of aquaporin 4 in 10 ug of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Rat Aquaporin 4 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen Region	Produced against the C-terminal peptide (Sequence N-CTKGSYMEVEDNRSQVETED) of rat aquaporin 4
Launch Date	2011/12/06
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human

Antigen	Aquaporin 4
Swissprot	P47863
Accession Number	NP_036957.1
Gene Id	25293
Research Area	Neurotransmission, Ion Channels, Aquaporins, Neuroscience

Concentration	1 mg/ml
Purification	Protein A Purified
Scientific Background	Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells (3). It is also expressed in astrocytes and is up regulated by direct insult to the CNS (4). Aquaporin 4 has been proposed as the primary autoimmune target in neuromyelitis optica ( 5, 6).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~35kDa. May detect larger glycosylated bands ~50kDa.
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, IHC, ICC/IF
Dilution	WB (1:2000), IHC (1:200), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396. 2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258. 3. Agre P., Nielsen S. (1996) Nephrologie. 17(7): 409-415. 4. Nagelhus E.A., Mathiisen T.M., Ottersen O.P. (2004) Neuroscience. 129(4): 905-913. 5. Lennon V.A., Kryzer T.J., Pittock S.J., Verkman A.S., Hinson S.R. (2005) J Exp Med. 202(4): 473-477. 6. Bradl M., Lassmann D.H. (2008) Int. MS Journal/MS Forum. 15(3): 75-78.

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Combination SKU	Supplier No.	Size	Conjugate	Your price	Quantity
BHA11907938-1	SPC-505D	100 ug	Unconjugated	$337		Add to Cart
BHA11907938-2	SPC-505D-A390	100 ug	ATTO 390	$392		Add to Cart
BHA11907938-3	SPC-505D-A488	100 ug	ATTO 488	$391		Add to Cart
BHA11907938-4	SPC-505D-A594	100 ug	ATTO 594	$391		Add to Cart
BHA11907938-5	SPC-505D-APC	100 ug	APC	$390		Add to Cart
BHA11907938-6	SPC-505D-BI	100 ug	Biotin	$386		Add to Cart
BHA11907938-7	SPC-505D-FITC	100 ug	FITC	$381		Add to Cart
BHA11907938-8	SPC-505D-HRP	100 ug	HRP	$377		Add to Cart
BHA11907938-9	SPC-505D-PCP	100 ug	PerCP	$390		Add to Cart
BHA11907938-10	SPC-505D-RPE	100 ug	RPE	$388		Add to Cart
BHA11907938-11	SPC-505S	12 ug	Unconjugated	$45		Add to Cart

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