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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human Truncated Tau dGAE (297-391) Polyclonal (SPC-806)

SKU : BHA11930002

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StressMarq Biosciences Inc.

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Mfr.No.	SPC-806, SPC-806D, SPC-806D-A390, SPC-806D-A488, SPC-806D-A594, SPC-806D-APC, SPC-806D-BI, SPC-806D-FITC, SPC-806D-HRP, SPC-806D-PCP, SPC-806D-RPE, SPC-806S
Immunogen Species	Human
Alternative Names	Tau Antibody, Neurofibrillary tangle protein Antibody, MAPTL Antibody, Microtubule-associated protein tau Antibody, MTBT1 Antibody, Paired helical filament-tau Antibody, TAU Antibody, PHF-tau Antibody, MAPT Antibody, AI413597 antibody, AW045860 antibody, DDPAC antibody, FLJ31424 antibody, FTDP 17 antibody, G protein beta1/gamma2 subunit interacting factor 1 antibody, MAPT antibody, MAPTL antibody, MGC134287 antibody, MGC138549 antibody, MGC156663 antibody, Microtubule associated protein tau antibody, Microtubule associated protein tau isoform 4 antibody, Microtubule-associated protein tau antibody, MSTD antibody, Mtapt antibody, MTBT1 antibody, MTBT2 antibody, Neurofibrillary tangle protein antibody, Paired helical filament tau antibody, Paired helical filament-tau antibody, PHF tau antibody, PPND antibody, PPP1R103 antibody, Protein phosphatase 1, regulatory subunit 103 antibody, RNPTAU antibody, TAU antibody, TAU_HUMAN antibody, Tauopathy and respiratory failure, included antibody, dGAE tau fibril antibody, Truncated Tau Fragment (AA297-391) antibody, 95-amino acid tau protein fragment antibody, Truncated Tau Protein antibody
Categories	Antibodies
Cellular Localization	Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex
Certificate Of Analysis	A 1:1000 dilution of SPC-806 was sufficient for detection of tau in 15 ug of mouse, rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Truncated Tau Fragment (AA297-391) (dGAE) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen Region	Recombinant Human Tau AA297-391 (dGAE) Fibril (SPR-461)
Launch Date	2020/08/07
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Widely expressed, with high levels in brain.

Antigen	Truncated Tau Fragment
Swissprot	P10636
Accession Number	NP_005901.2
Gene Id	4137
Research Area	Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton

Concentration	1mg/mL
Purification	Protein A
Scientific Background	Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~10.2 kDa.
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146148 (1907) 3. Al-Hilaly, Y.K. et al. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. J. Mol. Biol. 429(23):3650-3665 (2017)

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Combination SKU	Supplier No.	Size	Conjugate	Your price	Quantity
BHA11930002-1	SPC-806D	100 ug	Unconjugated	$337		Add to Cart
BHA11930002-2	SPC-806D-A390	100 ug	ATTO 390	$392		Add to Cart
BHA11930002-3	SPC-806D-A488	100 ug	ATTO 488	$391		Add to Cart
BHA11930002-4	SPC-806D-A594	100 ug	ATTO 594	$391		Add to Cart
BHA11930002-5	SPC-806D-APC	100 ug	APC	$390		Add to Cart
BHA11930002-6	SPC-806D-BI	100 ug	Biotin	$386		Add to Cart
BHA11930002-7	SPC-806D-FITC	100 ug	FITC	$381		Add to Cart
BHA11930002-8	SPC-806D-HRP	100 ug	HRP	$377		Add to Cart
BHA11930002-9	SPC-806D-PCP	100 ug	PerCP	$390		Add to Cart
BHA11930002-10	SPC-806D-RPE	100 ug	RPE	$388		Add to Cart
BHA11930002-11	SPC-806S	12 ug	Unconjugated	$45		Add to Cart

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