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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human p38 Polyclonal (SPC-172)

BHA11907001
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+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
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Antigen p38
Swissprot Q16539
Accession Number NP_001306.1
Gene Id 1432
Target p38
Research Area Cell Signaling, Post-translational Modifications, Phosphorylation, Cancer
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100), IP (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2alpha translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~43kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP
Dilution WB (1:1000), ICC/IF (1:100), IP (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Pearson G., et al (2001) Endocrine Reviews 22 (2): 153-183.

2. Fan Y., et al (2007) Mol. Cells 23 (1): 30-38.

3. Han J., et al. (1994) Science 265: 808-811.

4. Van L. A., et al. (2004) Faseb J. 18: 1946?1948.

5. Deng et al. (2003) Cell 115: 61-70.

6. Salojin K.V., et al. (2006) J Immunol. 176 (3):1899-907.

7. Medicherla S., et al. (2006) J Pharmacol Exp Ther. 318(1): 99-107.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907001-1 SPC-172D Unconjugated 100 ul $235
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BHA11907001-2 SPC-172D-A390 ATTO 390 100 ul $290
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BHA11907001-3 SPC-172D-A488 ATTO 488 100 ul $289
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BHA11907001-4 SPC-172D-A594 ATTO 594 100 ul $289
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BHA11907001-5 SPC-172D-APC APC 100 ul $288
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BHA11907001-6 SPC-172D-BI Biotin 100 ul $284
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BHA11907001-7 SPC-172D-FITC FITC 100 ul $279
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BHA11907001-8 SPC-172D-HRP HRP 100 ul $275
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BHA11907001-9 SPC-172D-PCP PerCP 100 ul $288
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BHA11907001-10 SPC-172D-RPE RPE 100 ul $285
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BHA11907001-11 SPC-172S Unconjugated 12 ul $45
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