Amyloid Oligomers (A11)

Mfr.No.	SPC-506, SPC-506D, SPC-506D-A390, SPC-506D-A488, SPC-506D-A594, SPC-506D-APC, SPC-506D-BI, SPC-506D-FITC, SPC-506D-HRP, SPC-506D-PCP, SPC-506D-RPE, SPC-506S
Immunogen Species	Human
Alternative Names	Amyloid Oligomer alpha beta Antibody, A11 Antibody, Amyloid Oligomer AlphaBeta Antibody, APP Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	A 1:200 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 ug of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Amyloid Oligomers (A11) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic molecular mimic of soluble oligomers, Homo Sapiens (Human)
Immunogen Region	Synthetic molecular mimic of soluble human amyloid beta oligomers
Launch Date	2012/01/13
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human, Eukaryote
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Eukaryote, Human

Antigen	Amyloid Oligomers
Swissprot	P05067
Accession Number	NM_000484.2
Gene Id	8666
Target	Amyloid
Research Area	Amyloid, Cell Signaling, Cardiovascular System, Blood, Neurodegeneration, Alzheimer's Disease, Neuroscience

Buffer	PBS, 50% glycerol, 0.09% sodium azide
Dilutions	WB (1:200), IP (1:200); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Storage	-20ºC
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, IHC, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP ; ELISA
Dilution	The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907957-1	SPC-506D	Unconjugated	100 ul	$324	Add to Cart
BHA11907957-2	SPC-506D-A390	ATTO 390	100 ul	$379	Add to Cart
BHA11907957-3	SPC-506D-A488	ATTO 488	100 ul	$378	Add to Cart
BHA11907957-4	SPC-506D-A594	ATTO 594	100 ul	$378	Add to Cart
BHA11907957-5	SPC-506D-APC	APC	100 ul	$377	Add to Cart
BHA11907957-6	SPC-506D-BI	Biotin	100 ul	$373	Add to Cart
BHA11907957-7	SPC-506D-FITC	FITC	100 ul	$368	Add to Cart
BHA11907957-8	SPC-506D-HRP	HRP	100 ul	$363	Add to Cart
BHA11907957-9	SPC-506D-PCP	PerCP	100 ul	$377	Add to Cart
BHA11907957-10	SPC-506D-RPE	RPE	100 ul	$374	Add to Cart
BHA11907957-11	SPC-506S	Unconjugated	12 ul	$45	Add to Cart

Rabbit Anti-Human Amyloid Oligomers (A11) Polyclonal (SPC-506)