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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Human Alpha Synuclein Polyclonal (SPC-800)

SKU : BHA11920127

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StressMarq Biosciences Inc.

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Mfr.No.	SPC-800, SPC-800D, SPC-800D-A390, SPC-800D-A488, SPC-800D-A594, SPC-800D-APC, SPC-800D-BI, SPC-800D-FITC, SPC-800D-HRP, SPC-800D-PCP, SPC-800D-RPE, SPC-800S
Immunogen Species	Human
Alternative Names	Alpha Synuclein Antibody, Non-A4 component of amyloid precursor Antibody, MGC105443 Antibody, OTTHUMP00000218552 Antibody, MGC110988 Antibody, OTTHUMP00000218553 Antibody, Synuclein alpha 140 Antibody, alphaSYN Antibody, Parkinson disease familial 1 Antibody, OTTHUMP00000218554 Antibody, Parkinson disease (autosomal dominant, Lewy body) 4 Antibody, Synuclein, alpha (non A4 component of amyloid precursor) Antibody, OTTHUMP00000218549 Antibody, Non A4 component of amyloid precursor Antibody, MGC127560 Antibody, SYN Antibody, SNCA Antibody, MGC64356 Antibody, Non A4 component of amyloid Antibody, PARK4 Antibody, Alpha synuclein Antibody, PARK 1 Antibody, Snca synuclein, Synuclein alpha Antibody, Non-A4 component of amyloid, precursor of Antibody, OTTHUMP00000218551 Antibody, PARK 4 Antibody, PARK1 Antibody, Alpha-synuclein, isoform NACP140 Antibody, Non-A-beta component of alzheimers disease amyloid, Non-A beta component of AD amyloid Antibody, NACP Antibody, SYUA_HUMAN Antibody, Alpha-synuclein Antibody, Non A beta component of AD amyloid Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Membrane, Nucleus, Cell Junction, Synapse, Secreted
Certificate Of Analysis	A 1:1000 dilution of SPC-800 was sufficient for detection of Alpha Synuclein in 15 ug of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Alpha Synuclein Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide from the full length of Human Alpha Synuclein, Homo Sapiens (Human)
Immunogen Region	Recombinant Human alpha Synuclein Fibril
Launch Date	2018/11/21
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Highly expressed in brain (presynaptic nerve terminals) but is also expressed in low concentrations in all tissues examined except in liver.

Antigen	Alpha Synuclein
Swissprot	P37840
Accession Number	NP_000336.1
Gene Id	6622
Target	Alpha Synuclein
Research Area	Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience

Concentration	1 mg/ml
Purification	Protein A Purified
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~14.46kda.
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, WB, IHC
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

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Combination SKU	Supplier No.	Conjugate	Size	Your price	Quantity
BHA11920127-1	SPC-800D	Unconjugated	100 ug	$337		Add to Cart
BHA11920127-2	SPC-800D-A390	ATTO 390	100 ug	$392		Add to Cart
BHA11920127-3	SPC-800D-A488	ATTO 488	100 ug	$391		Add to Cart
BHA11920127-4	SPC-800D-A594	ATTO 594	100 ug	$391		Add to Cart
BHA11920127-5	SPC-800D-APC	APC	100 ug	$390		Add to Cart
BHA11920127-6	SPC-800D-BI	Biotin	100 ug	$386		Add to Cart
BHA11920127-7	SPC-800D-FITC	FITC	100 ug	$381		Add to Cart
BHA11920127-8	SPC-800D-HRP	HRP	100 ug	$377		Add to Cart
BHA11920127-9	SPC-800D-PCP	PerCP	100 ug	$390		Add to Cart
BHA11920127-10	SPC-800D-RPE	RPE	100 ug	$388		Add to Cart
BHA11920127-11	SPC-800S	Unconjugated	12 ug	$45		Add to Cart

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