HSP110

Mfr.No.	SPC-195, SPC-195D, SPC-195D-A390, SPC-195D-A488, SPC-195D-A594, SPC-195D-APC, SPC-195D-BI, SPC-195D-FITC, SPC-195D-HRP, SPC-195D-PCP, SPC-195D-RPE, SPC-195S
Immunogen Species	Hamster
Alternative Names	Heat shock 105kDa alpha Antibody, heat shock 105kDa beta Antibody, HSP105 Antibody, HSP105A Antibody, HSP105B Antibody, HSP110 Antibody, HSPH1 Antibody, NY CO 25 Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm
Certificate Of Analysis	1 ug/ml of SPC-195 was sufficient for detection of HSP110 in 10 ug of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Hamster HSP110 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse, Mesocricetus Auratus Polyomavirus 1
Immunogen Region	Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse
Launch Date	2010/02/23
Net Weight (g)	0.1
Reactivity	Gummy Shark, School Shark, Rat, Sheep, Yeast, Mouse, Human, Monkey, Bovine, Hamster, Shark
Recombinant	FALSE
Regulatory	RUO
Species	Mesocricetus Auratus Polyomavirus 1
Species Reactivity Medium	Mouse, Rat, Bovine, Monkey, Hamster, Sheep, Yeast, Shark, Human

Antigen	HSP110
Swissprot	Q92599
Accession Number	NP_006635.3
Gene Id	10808
Target	HSP110
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking

Buffer	PBS pH7.2, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	HSP110 belongs to a family of large stress proteins known as the HSP110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied HSP70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain (1). HSP110 cooperates with HSP70 in protein folding in the eukaryotic cytosol (2). In mammals, HSP110 is constitutively expressed, but exhibits particularly high levels in the brain. Both HSP70 and HSP110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of HSP110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of HSP70 (3). Studies also suggest that HSP110 can be used in heat shock protein-based cancer immunotherapy (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~110kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC
Dilution	WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Lee-Yoon D., et al. (1995) J Biol Chem. 270: 15725-15733. 2. Dragovic Z., et al. (2006) EMBO J. 25: 2519-2528. 3. Nakamura J., et al. (2008) Stroke. 39(10): 2853-2859. 4. Subject D.R. (2001) Health Research Inc. Report number AS90893: 1-84.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907298-1	SPC-195D	Unconjugated	100 ug	$282	Add to Cart
BHA11907298-2	SPC-195D-A390	ATTO 390	100 ug	$337	Add to Cart
BHA11907298-3	SPC-195D-A488	ATTO 488	100 ug	$336	Add to Cart
BHA11907298-4	SPC-195D-A594	ATTO 594	100 ug	$336	Add to Cart
BHA11907298-5	SPC-195D-APC	APC	100 ug	$335	Add to Cart
BHA11907298-6	SPC-195D-BI	Biotin	100 ug	$332	Add to Cart
BHA11907298-7	SPC-195D-FITC	FITC	100 ug	$326	Add to Cart
BHA11907298-8	SPC-195D-HRP	HRP	100 ug	$322	Add to Cart
BHA11907298-9	SPC-195D-PCP	PerCP	100 ug	$335	Add to Cart
BHA11907298-10	SPC-195D-RPE	RPE	100 ug	$333	Add to Cart
BHA11907298-11	SPC-195S	Unconjugated	12 ug	$45	Add to Cart

Rabbit Anti-Hamster HSP110 Polyclonal (SPC-195)