A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate(PtdInsP3) and phosphatidic acid(PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment(ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Categories
Primary Antibodies
Clonality
polyclonal
Description
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Host
Rabbit
Immunogen
RAB11 family interacting protein 2(class I)
Isotype
IgG
Molecular Weight
58 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
KIAA0941
Antigen
RAB11FIP2
Uniprot
Q7L804
Gene Id
22841
Research Area
Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)