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Home / Primary Antibodies / Polyclonal Antibodies

Presenilin 2 (phospho Ser330) Rabbit pAb

SKU : BHA15205850

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ELK Biotechnology

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Mfr.No.	ES6849
Antigen	Presenilin 2 (phospho Ser330)
Background	Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Clonality	Polyclonal
Conjugate	Unconjugate
Host	Rabbit
Immunogen	Synthesized peptide derived from human Presenilin 2 around the phosphorylation site of S330.
Isotype	IgG
Reactivity	Human, Mouse, Rat

Gene Id	5664

Concentration	1mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ELISA

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA15205850	ES6849	50µl	$148		Add to Cart
BHA15205850	ES6849	100µl	$248		Add to Cart

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