Paraoxonase 1, also known as Aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. This protein has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the gene significantly affect the catalytic ability of the enzyme. Paraoxonase 1 is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The gene is activated by PPAR-gamma, which increases synthesis and release of PON1 enzyme from the liver, reducing atherosclerosis.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the middle region of human Paraoxonase 1 (FLDPYLQSWEMYLGLA) was used as the immunogen for this PON1 antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Antigen
PON1
Uniprot
P27169
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the PON1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.