This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids KTDLSNVQELLQFVKANDDVAQEIAER from the human protein were used as the immunogen for the POGLUT1 antibody.
Isotype
Rabbit IgG
Species Reactivity
Human, Mouse
Note
Optimal dilution of the POGLUT1 antibody should be determined by the researcher.
Uniprot
Q8NBL1
Format
Antigen affinity purified
Purity
Affinity purified
Storage
After reconstitution, the POGLUT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Applications
IF, IHC-P, WB
Description
Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence: 5ug/ml