Solute carrier family 22 (organic cation/carnitine transporter) member 5, also called SLC22A5 or OCTN2 is a membrane transport protein associated with primary carnitine deficiency. This gene is mapped to 5q31.1. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency(CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of mouse SLC22A5/OCTN2 (KQWQIQSQTRMQKDGEE) was used as the immunogen for this OCTN2 antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Rat, Mouse
Recombinant
No
Antigen
OCTN2
Uniprot
Q9Z0E8
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the OCTN2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.