NPPB, also known as B-type natriuretic peptide (BNP), is a cardiac hormone that is secreted mainly in the ventricles in response to increased wall stress. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. BNP is a marker of systolic and diastolic dysfunction and a strong predictor of mortality in heart failure patients.
Clonality
polyclonal
Host
Rabbit
Immunogen
natriuretic peptide precursor B
Immunogen Region
natriuretic peptide precursor B
Isotype
IgG
Molecular Weight
15 kDa
Reactivity
Human
Recommended Dilution
IHC: 1:20-1:200
Synonyms
BNP, BNP(1 32), Natriuretic peptides B, NPPB
Uniprot
P16860
Gene Id
4879
Research Area
Stem Cells, Cardiovascular
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09840.pdf" target="_blank">Data Sheet</ a>