Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT(AG)-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Host
Rabbit
Immunogen
NK3 homeobox 1
Isotype
IgG
Molecular Weight
36kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
NKX3.1, NKX3A
Antigen
NKX3-1
Uniprot
Q99801
Gene Id
4824
Research Area
Epigenetics, Developmental biology, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)