Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Host
Rabbit
Immunogen
neuroepithelial cell transforming 1
Isotype
IgG
Molecular Weight
62-68 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
ARHGEF8
Antigen
NET1
Uniprot
Q7Z628
Gene Id
10276
Research Area
Signal Transduction, Metabolism, Cancer, Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)