Myoglobin (MB) also known as PVALB, is a single-chain globular protein of 153 or 154 amino acids, containing a heme (iron-containing porphyrin) prosthetic group in the center around which the remaining apoprotein folds. Two structural variants of myoglobin were described by Boyer et al.(1963). Boulton et al.(1969) studied postmortem muscle from 2,500 people. Two Myoglobin variants were found, and in one of these substitution of lysine for glutamic acid at residue 53 was demonstrated. MG was the first protein to have its three-dimensional structure revealed. Jeffreys et al.(1984) used DNA probes isolated from the cloned gene to map the gene in human-rodent somatic cell hybrids. The locus mapped to chromosome 22q11-q13. MG is released from damaged muscle tissue (rhabdomyolysis), which has very high concentrations. The released MG is filtered by the kidneys but is toxic to the renal tubular epithelium and so may causeacute renal failure.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human Myoglobin (LFRKDMASNYKELGFQG) was used as the immunogen for this Myoglobin antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
Myoglobin
Uniprot
P02144
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the Myoglobin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.