Modulator of melanocortin receptor 4(MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP(By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin(ACTH) to MC2R. May also regulate activity of other melanocortin receptors(MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Host
Rabbit
Immunogen
melanocortin 2 receptor accessory protein 2
Isotype
IgG
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
C6orf117
Antigen
MRAP2
Uniprot
Q96G30
Gene Id
112609
Research Area
Signal Transduction, Immunology, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)