Hepatocyte nuclear factor 1 homeobox B, also known as Transcription factor 2 (TCF2), is a human gene. It is a member of the homeodomain-containing superfamily of transcription factors. The HNF1B protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1. It functions as both a classic transcriptional activator and as a bookmarking factor that marks target genes for rapid transcriptional reactivation after mitosis. HNF1B also can regulate renal tubulogenesis by controlling expression of SOC3. A mutation of the protein that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5).
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human Hepatocyte nuclear factor 1 homeobox B (HMAQQPFMAAVTQLQN) was used as the immunogen for this HNF1B antibody (100% homologous in human, mouse and rat).
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Antigen
HNF1B
Uniprot
P35680
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the HNF1B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.