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Home / Primary Antibodies / Polyclonal Antibodies

HDAC3 Antibody

SKU : BHA17118984

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Mfr.No.	RQ5284
Clonality	Polyclonal (rabbit origin)
Description	HDAC3 (HISTONE DEACETYLASE 3) is a member of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC3 gene. The HDAC3 gene is mapped to 5q31.3. HDAC3 has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. The protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. And this gene is regarded as a potential tumor suppressor gene. HDAC3 has an open reading frame of 428 amino acids and shares 53% amino acid identity with HDAC1 and 52% with HDAC2. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. All experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 resulted in loss of enzymatic activity associated with HDAC4. HDAC3 recruitment to the genome displays a circadian rhythm in mouse liver.
Host	Rabbit
Immunogen Region	Amino acids M1-I428 from the human protein were used as the immunogen for the HDAC3 antibody.
Isotype	Rabbit IgG
Reactivity	Human
Recombinant	No

Antigen	HDAC3
Uniprot	O15379

Buffer	Lyophilized from 1X PBS with 2% Trehalose
Concentration	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format	Antigen affinity purified
Purification	Antigen affinity purified
Storage	Store the HDAC3 antibody at -20oC.

Applications	Direct ELISA, WB
Dilution	Western blot: 0.5-1ug/ml, Direct ELISA: 0.1-0.5ug/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA17118984	RQ5284	100ug	$439		Add to Cart

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