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Home / Primary Antibodies / Polyclonal Antibodies

Guinea Pig Anti-Aquaporin 4 (AQP4) (300-314) Antibody

SKU : BHA21301207

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Alomone Labs

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Mfr.No.	AQP-014-GP, AQP-014-GP-CF_0.2 ml, AQP-014-GP_0.2 ml, AQP-014-GP_25 mcl, AQP-014-GP_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Aquaporin 4 (AQP-4) belongs to a family of membrane proteins that allow passage of water and certain solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permeability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. AQP-4 together with AQP-1, AQP-2 and AQP-5 belong to the first group1. Little is known about the function of the two newest members, AQP-11 and AQP-12.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1.AQP-4 is the major membrane water channel in the central nervous system. The channel is expressed in astrocyte foot processes in direct contact with capillary vessels in the brain suggesting a role in water transport under normal and pathological conditions. Indeed, transgenic mice lacking AQP-4 have reduced brain swelling and improved neurological outcome following water intoxication and focal cerebral ischemia. In contrast, brain swelling and clinical outcome are worse in AQP-4-null mice in models of vasogenic (fluid leak) edema caused by freeze-injury and brain tumor, probably due to impaired AQP-4-dependent brain water clearance2.In addition, it has been recently shown that neuromyelitis optica (NMO), an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord, is caused by the development of an autoantibody directed against AQP-43.
Clonality	Polyclonal
Description	Guinea Pig Anti-Aquaporin 4 (AQP4) (300-314) Antibody (#AQP-014-GP) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Aquaporin 4 from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-Aquaporin 4 (AQP4) (300-314) (#AQP-014) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.
Formulation	PBS pH7.4
Host	Guinea Pig
Immunogen Region	Intracellular, C-terminus
Isotype	Guinea pig total IgG
Reactivity	Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	WCH4, Mercurial-insensitive water channel, MIWC
UNSPSC Code	41116161
Note	Homology: Mouse - 14/15 amino acid residues identical; human - 13/15 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-QP014 Specifictiy: AQP4 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P47863
Gene Id	25293
Target	WCH4, Mercurial-insensitive water channel, MIWC
Sequence	(C)HVIDIDRGDEKKGKD, corresponding to amino acid residues 300-314 of rat AQP4

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IHC, WB
Dilution	1:200-1:300

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301207-1	AQP-014-GP-CF_0.2 ml	0.2 ml	$994		Add to Cart
BHA21301207-2	AQP-014-GP_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301207-3	AQP-014-GP_25 mcl	25 mcl	$597		Add to Cart
BHA21301207-4	AQP-014-GP_50 mcl	50 mcl	$697		Add to Cart

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