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Home / Primary Antibodies / Polyclonal Antibodies

GHR Antibody / Growth Hormone Receptor

SKU : BHA17104377

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NSJ Bioreagents

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Mfr.No.	R30816
Clonality	Polyclonal
Description	The Growth hormone receptor is found on human chromosome 5p13.1-p12 and mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. The Growth hormone receptor consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are two isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3 (d3GHR). The two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the Growth hormone receptor gene have been demonstrated as the cause of Laron syndrome , also known as the growth hormone insensitivity syndrome (GHIS).
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the middle region of mouse Growth hormone receptor (DKEHEVRVRSRQRSFEK) was used as the immunogen for this GHR antibody (100% rat homology).
Isotype	IgG
Predicted Reactivity	Mouse, Rat
Reactivity	Rat, Mouse
Recombinant	No

Antigen	GHR
Uniprot	P16882

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the GHR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Western blot: 0.5-1ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17104377-1	R30816	100ug	$439		Add to Cart

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