Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links(ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA(ssDNA) and double-stranded DNA(dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays an essential role in the repair of DNA double- strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Host
Rabbit
Immunogen
Fanconi anemia, complementation group I
Isotype
IgG
Molecular Weight
150 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
KIAA1794
Antigen
FANCI
Uniprot
Q9NVI1
Gene Id
55215
Research Area
Epigenetics, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)