Estrogen receptor-beta, referred to as ESR2 or ER<font face=symbol>b</font>, is a member of the superfamily of nuclear receptors which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb. It is expressed in multiple tissues, including developing spermatids of the testis and in ovarian granulosa cells. ER<font face=symbol>b</font> is homologous to the previously identified ER<font face=symbol>a</font> and has an overlapping but nonidentical tissue distribution. The DNA-binding domain of ER<font face=symbol>b</font> is 96% conserved compared to ER<font face=symbol>a</font>, and the ligand-binding domain shows 58% conserved residues. Estrogen receptor beta is expressed in human thymus, spleen, ovary, and testis. ER<font face=symbol>b</font> mRNA was coexpressed with ER<font face=symbol>a</font> and its splice variants in 60% of prolactinomas, 100% of mixed growth hormone /prolactin tumors, and 29% of gonadotroph tumors. Gene expression was not limited to ERa-positive tumor subtypes, however, and was also found in 100% of null cell tumors, 80% of somatotroph tumors, and 60% of corticotroph tumors.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the N-terminus of human Estrogen Receptor beta (HGSIYIPSSYVDSHHEYPAMTFYS) was used as the immunogen for this Estrogen Receptor antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
Estrogen Receptor
Uniprot
Q92731
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the Estrogen Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.