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Home / Primary Antibodies / Polyclonal Antibodies

DUSP6 Antibody

SKU : BHA17119120

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NSJ Bioreagents

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Mfr.No.	RQ6707
Clonality	Polyclonal (rabbit origin)
Description	Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
Host	Rabbit
Immunogen Region	Recombinant human protein (amino acids M1-T381) was used as the immunogen for the DUSP6 antibody.
Isotype	Rabbit IgG
Reactivity	Rat, Mouse, Human
Recombinant	No

Antigen	DUSP6
Uniprot	Q16828

Buffer	Lyophilized from 1X PBS with 2% Trehalose
Concentration	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format	Antigen affinity purified
Purification	Antigen affinity purified
Storage	After reconstitution, the DUSP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Applications	Direct ELISA, FACS, IF, IHC-P, WB
Dilution	Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119120	RQ6707	100ug	$439		Add to Cart

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