Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene. The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids NAELRGRLLAGAYHAVVLLDERSAALD from the human protein were used as the immunogen for the DUSP1 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
DUSP1
Uniprot
P28562
Format
Antigen affinity purified
Purification
Affinity purified
Storage
After reconstitution, the DUSP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
WB, FACS
Dilution
Western blot: 1-2ug/ml,Flow cytometry: 1-3ug/million cells